Pentylenetetrazol produces a state-dependent conditioned place aversion to alcohol withdrawal in mice

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Pentylenetetrazol produces a state-dependent conditioned place aversion to alcohol withdrawal in mice.

The purpose of this study was to determine if aversive effects of alcohol withdrawal could be detected in mice using the place conditioning procedure and whether the GABA(A) receptor antagonist, pentylenetetrazol (PTZ), would increase the aversive effects of alcohol withdrawal and increase the probability of detecting conditioned place aversion. Subjects were alcohol-naïve mice from a specific ...

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ژورنال

عنوان ژورنال: Pharmacology Biochemistry and Behavior

سال: 2010

ISSN: 0091-3057

DOI: 10.1016/j.pbb.2010.02.001